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Retrieved from Isaacs, D

Tryptophan-derived metabolites, such as indole and its derivatives, influence bacterial biofilm formation and pathogenicity through AhR-mediated pathways, concurrently influencing host immunological responses 47

This helps us narrow down the possible reasons for your discomfort

After reviewing the evidence, the European Medicines Agency recommended updating the product information for semaglutide medicines Ozempic, Rybelsus and Wegovy to list NAION as a side effect classified as very rare , and the World Health Organization issued a safety alert in June 2025

So, if youre taking these medications, please let your doctor know if you are planning any surgery or any procedure that involves anesthesia or deep sedation