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If constipation-predominant IBS worsens significantly or diarrhea-predominant IBS shifts to severe constipation, medication adjustment may be necessary
But the differences between them particularly the addition of glucagon receptor (GCGR) agonism in retatrutide produce meaningfully distinct experimental profiles that influence which compound belongs in a given study design
[11] [1] Bloody or black tarry stools require urgent evaluation to exclude gastrointestinal bleeding
This is backed by recent research , which found that between 2022 and 2024, GLP-1 use increased five-fold among women whod given birth within the past six months
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