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When to seek urgent medical help: Whilst most gastrointestinal side effects are mild and self-limiting, participants and clinicians should be alert to the following red-flag symptoms, which require prompt medical assessment: Severe or persistent abdominal pain (which may indicate pancreatitis or gallbladder disease) Repeated vomiting or an inability to keep fluids down Signs of dehydration (such as dizziness, dark urine, or reduced urine output) Yellowing of the skin or eyes (jaundice) Anyone who suspects they have experienced a side effect from a medicine including medicines received as part of a clinical trial should report it via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)
Once-weekly semaglutide doubles the five-year risk of nonarteritic anterior ischemic optic neuropathy in a Danish cohort of 424,152 persons with type 2 diabetes
Between 2019 and 2024, prescriptions for GLP-1 drugs rose 587%
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The STEP 1 trial showed average weight loss of 14.9% over 68 weeks, with around half of participants losing 15% or more of their body weight
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