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Hypoxia causes the upregulation of nitroreductase with 1001000-fold higher concentration than normoxic cells

The colour of the lesion may be black (especially in dark skinned individuals), brown (junctional naevus), skin coloured or pink (cellular or dermal naevus), steel-blue (blue naevus)

Rosen CJ, Ingelfinger JR

Several gut hormones secreted by enterocytes are responsible for appetite control

This mechanism enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon release, and slows gastric emptying, which collectively improves glycemic control and promotes satiety