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Immediate medical attention is necessary if patients experience: Persistent vomiting lasting more than 24 hours or inability to keep down any fluids Signs of dehydration , including decreased urination, dark urine, dizziness, dry mouth, or confusion Severe abdominal pain , particularly if constant, sharp, or radiating to the back (potential pancreatitis) Vomiting blood or material that looks like coffee grounds Signs of gastroparesis , such as feeling full after eating very small amounts, severe bloating, or vomiting undigested food hours after eating Right upper quadrant pain, fever, or yellowing of skin/eyes , which may indicate gallbladder disease (a known risk with GLP-1 receptor agonists) [7] [8] Patients should contact their healthcare provider within 24-48 hours if they experience moderate vomiting that interferes with daily activities, prevents adequate nutrition or medication intake, or does not improve with conservative measures

M., Saluja, J., Sannidhi, D., Fatima Cody, S., & Callahan, E

That does not mean oral therapy is interchangeable with injectables, but it does mean provider flexibility matters more now

J Diabetes Invest 1(1-2):823

Lower net acquisition costs for GLP-1 medications would strengthen the economic case for maintaining or adding GLP-1 coverage for obesity