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[8] [20] Beyond nausea, patients commonly experience a constellation of gastrointestinal symptoms including: Vomiting (reported in 24% of semaglutide users) Diarrhea (affecting 30% of patients) Constipation (occurring in 24% of users) Abdominal pain or discomfort (experienced by 20% of patients) Bloating and excessive gas Acid reflux or heartburn Decreased appetite (which, while therapeutic, can feel uncomfortable) The severity of these symptoms typically ranges from mild to moderate, and most patients do not discontinue treatment due to nausea alone

Separate analyses were performed in T2DM patients with and without obesity

Typically produced in the intestinal tract, GLP-1, when secreted, performs two critical actions: it stimulates the release of insulin and inhibits the release of glucagon

Participants were excluded if they had a self-reported diagnosis of psychiatric disorders not subject of NESDA (e.g