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A systematic review and meta-analysis of capsaicinoid trials found it reduced ad libitum energy intake at meals by an average of roughly 74 calories per meal
J Cardiopulm Rehabil Prev
For example, other drug makers might pursue this approach going forward, compared to the more rigorous FDA approval pathway
Despite these developments, significant obstacles remain, including tumor heterogeneity, complex resistance mechanisms, off-target effects, and limited predictive biomarkers
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