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Furthermore, excessive ROS generation can disrupt nitric oxide (NO) homeostasis by reducing endothelial nitric oxide synthase (eNOS) activity, while upregulating inducible nitric oxide synthase (iNOS), leading to impaired vasodilation and exacerbated venous stasis [11]

Liu H, Qiu W, Sun T, Wang L, Du C, Hu Y, et al

Ethics declarations The authors of this work declare that they have no conflicts of interest

Peptide therapy can be beneficial for a wide range of individuals, depending on their specific health needs and goals

Maruyama-Nakashita A, Nakamura Y, Tohge T et al (2006) Arabidopsis SLIM1 Is a central transcriptional regulator of plant sulfur response and metabolism