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Unlike earlier GLP-1 receptor agonists like semaglutide (Ozempic/Wegovy) that target a single hormone pathway, or tirzepatide (Mounjaro/Zepbound) that targets two, retatrutide activates three distinct metabolic receptors : GIP, GLP-1, and glucagon

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Eli Lilly $LLY announced today that the drug behind Zepbound was found to help cut heart failure risks in patients with obesity in a late-stage clinical trial

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Cardiovascular exercise improves the metabolic adaptations that semaglutide initiates

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