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Semaglutide is a GLP-1 receptor agonist, primarily used to treat type 2 diabetes and obesity

That analysis came from a relatively small subpopulation of just 55 patients who underwent whole-body MRI scanning, which showed that the reduction in lean muscle mass with treatment, which raises concerns about loss of physical strength, mobility, and metabolic health, was around 10%

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FDA enforcement tightened against non-503B compounded semaglutide in 2025