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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants
2023, 15.: 10.3390/nu15081843 Schaffer S, Kim HW: Effects and Mechanisms of Taurine as a Therapeutic Agent
A novel and compact review on the role of oxidative stress in female reproduction
The intra-rater agreement and the inter-rater agreement calculated by the Cohens K coefficient for the two observers were 0.88 and 0.78, respectively
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