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Both produce satiety, but in different brain regions

Buse, M.D., from the University of North Carolina School of Medicine in Chapel Hill, and colleagues randomly assigned 2,713 adults with inadequately controlled type 2 diabetes receiving metformin with or without SGLT2i with overweight or obesity to receive cagrilintide-semaglutide, semaglutide, cagrilintide, or placebo for 68 weeks

This is crucial because the degenerative process of autoimmune disease destroys the mitochondria in affected cells, such as thyroid tissue in Hashimotos