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With how little we know about the experimental compound, its long term effects, potential negative side effects, etc., I do think it would be irresponsible to recommend it to others, especially athletes one is coaching
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Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6
People willing to commit to longer treatment and able to tolerate possible GI side effects
Less DHT
