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As a GHRH secretagogue that is subcutaneously injected, ipamorelin likely causes side effects related to frequent injections such as pain, rash or soreness at injection sites, in common with other forms of GH therapies [19]

Although the steric bulk of the (CH 2 )3 side chain might diminish activity relative to the natural GLP-1R agonists, these replacements should test the hypothesis that GLP-1R agonist activity is higher for ligands that can access non-helical conformations near the N-terminus, compared to those that cannot

It also boosts IGF-1, a compound that can help build lean muscle mass

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