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A 2021 review in Frontiers in Pharmacology organised the wound-healing literature by tissue category, covering dermal, tendon, ligament, skeletal-muscle, osseous, peripheral-nerve, and vascular models (PMID 34267654)
Why Deficiency Matters Even mild deficiency can cause wide-ranging symptoms: Persistent fatigue or low energy Brain fog, mood changes, or poor concentration Tingling or numbness in hands and feet Pale skin or shortness of breath Reduced immune function These occur because B12 is critical for oxygen transport and nerve conduction
If you feel exhausted no matter how much you rest, your B12 levels may be to blame
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