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Across preclinical research, BPC-157 has been reported to have a favorable tolerability profile: a 2021 Frontiers in Pharmacology review noted no reported toxicity in animal studies, with the LD1 (lethal dose for 1% of animals) not reached

For purely local models, BPC-157 is often sufficient at lower doses, which offsets the price advantage

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The most commonly reported ghk-cu side effects are injection-site reactions: localized redness, mild swelling, or transient pain at the injection point