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Phentermine is a Schedule IV controlled substance (DEA-classified for misuse potential), whereas semaglutide is not controlled
Meier JJ, Gallwitz B, Salmen S, Goetze O, Holst JJ, Schmidt WE, et al
Among them, dimethyl biguanide (known as metformin) was selected for clinical development with the suggestive name of Glucophage, which means glucose eater. The other biguanides, phenformin and buformin, were more potent than metformin, however in the late 1970s they were removed in most countries because of their association with lactic acidosis (Kathuria et al., 2021)
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