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10.1186/s40168-020-00845-6 487 XieX.WangL.DongS.GeS.ZhuT
Methods for inhibiting the HIF response to hypoxia include siRNA treatment, blocking the dimerization of HIF-1 and subunits, and direct inhibition of HIF-1 using anticancer agents known to inhibit the PI3K/AKT/HIF-1 pathway
One-Carbon metabolism in health and disease
Manifestations of glutathione synthetase deficiency usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs
The formula grows substantially larger with these modifications
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