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Transforming body composition with semaglutide in adults with obesity and type 2 diabetes mellitus
Investigating the changes in food and taste perception is of paramount interest to further understand the mechanisms of drug treatments for obesity
In the SURMOUNT-1 clinical trial, patients taking the highest approved dose (15 mg weekly) achieved average weight reductions of approximately 20% of their initial body weight over 72 weeks, compared to about 3% with placebo
The GLP-1 receptor (GLP-1R) is an established drug target for the treatment of diabetes and obesity 2 , whereas the therapeutic potential of the GIP receptor (GIPR) is a subject of debate
[4] [5] Gastrointestinal side effects are common with Rybelsus, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation
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