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Compared to other class B GPCRs, including the glucagon and glucose-dependent insulinotropic polypeptide receptors (GCGR, GIPR), endocytosis of the GLP-1R is rapid and extensive (61, 73), which could quickly lead to depletion of plasma membrane receptors, particularly when combined with preferential targeting to lysosomal degradation, a situation in which the biosynthetic pathway might not be able to replenish the pool of membrane receptors with sufficient efficiency

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BPC-157 builds the vascular infrastructure and controls inflammation