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Indeed, pyridoxal phosphate, the active form of pyridoxine, has been found to have independent neuroprotective potential

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Type 1 diabetes is caused by the autoimmune destruction of the insulin-producing -cells of the pancreas, leading to an insufficient production of insulin

Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis

One can also determine a quantal dose-response curve for the therapeutic effect of a drug to generate a median effective dose ( ED 50 ), the concentration of drug at which 50% of the population will have the desired response, and a quantal dose-response curve for lethality by the same agent