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if more than four days have passed, the missed dose should be skipped, and the regular schedule resumed

Pick a day each week and stick with it

To date, no pharmacological intervention currently is approved that directly addresses myocardial fibrosis [10]

Renal Impairment and Outcomes in Heart Failure Systematic Review and Meta-Analysis

If your question is purely about maximizing free growth factor availability in an experimental system, either will serve and the choice becomes practical