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Both cagrilintide and retatrutide have specific contraindications and populations requiring special consideration [19]: Absolute Contraindications: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to either compound Pregnancy or breastfeeding (insufficient safety data) Relative Contraindications Requiring Careful Evaluation: History of pancreatitis Severe gastroparesis or GI motility disorders Active gallbladder disease Severe renal impairment History of eating disorders Concurrent use of other appetite suppressants The cagrilintide dosage with retatrutide combination would carry all contraindications for both compounds, plus additional caution due to unknown interactions

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While the study reported improved healing, only BPC-157 appeared to have exhibited consistent results in all wound types (i.e., chronic and acute) on the esophagus, stomach, duodenum, and lower GI tract

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PCAC review (July 2026) The FDA stated it intends to consult the Pharmacy Compounding Advisory Committee on July 23, 2026 regarding inclusion of BPC-157 acetate and BPC-157 (free base) on the 503A bulks list