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In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis
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Inhibiting the enzyme therefore has consequences on two fronts at once: it spares S-adenosylmethionine, and it leaves nicotinamide available to other routes, including the salvage pathway that supplies NAD
