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Another essential aspect is ensuring an adequate intake of the amino acids glycine and cysteine, which are the building blocks for glutathione synthesis
Retinol activates nuclear retinoic acid receptors and drives collagen gene transcription, but frequently causes irritation, peeling, and photosensitivity at therapeutic concentrations
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Under hypoxia, the balance of Bcl-2 family proteins in tumors is disrupted, and the proapoptotic proteins BIM [255] and Bax [256] are inhibited, whereas the antiapoptotic proteins Bcl-2 [257], Bcl-xl [257], and Mcl-1 [258] are upregulated, thus increasing the apoptotic threshold and reducing the efficacy of chemotherapy and radiotherapy
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