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However, in the striatum, which is located in the subcortical forebrain, insulin influences dopamine reuptake and release, with IR opposing these effects, impacting neuronal excitatory projections [90]
Patients should maintain realistic expectations and continue treatment as prescribed, even if immediate improvements are not apparent, as premature discontinuation can lead to symptom recurrence
Many plans also require: Prior authorization Documentation of medical necessity Records of previous weight-management efforts Ongoing monitoring by a healthcare provider Some plans may require step therapy, meaning lower-cost treatments must be tried before Wegovy is approved
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