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The inclusion of KPV further supports immune regulation and anti-inflammatory pathways, expanding the experimental scope of this blend in preclinical settings
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
All three must be present to inhibit activity of this enzyme
This makes the combination particularly well suited to mechanistic studies of receptor cross-talk, signal amplification, and pulse generation that single-receptor models cannot adequately replicate [2][3]
doi: 10.1016/j.cell.2015.03.011 80 MakinoYNakamuraHIkedaEOhnumaKYamauchiKYabeYet al
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