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In uninjured homeostatic muscles, most MuSCs are quiescent with typical features of quiescent cells, such as reduced RNA and protein contents, small cell size with few mitochondria, a high nucleus-to-cytoplasm ratio, and a low metabolic rate 1,4,7,8
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Several harmful processes induced by hyperglycemia, including AGE formation, are associated with overproduction of a free radical called superoxide
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