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As duas principais incretinas no corpo humano so o GLP-1 (peptdeo 1 semelhante ao glucagon) e o GIP (polipeptdeo inibidor gstrico)
Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis
The SmPC notes that injectable semaglutide has not shown clinically relevant effects on the absorption of tested oral medicines, and routine dose adjustments are not required
Collaboration between a nephrologist and an endocrinologist is crucial before starting treatment
This creates a double safety barrier
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