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The complementary nature of the desirable attributes in GLP-1, GIP and GCG led to the creation of a unimolecular hybridised triagonist with retained and balanced activity across the GLP-1R, GIP receptor (GIPR) and GCGR [1]
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Peer review Peer review information Nature Medicine thanks Chiara Gastaldon, Hongjiang Wu and Tanja Stamm for their contribution to the peer review of this work
MHO is characterized by two or fewer metabolic syndrome componentssuch as normal glucose and lipid levels and an absence of hypertensionin contrast to metabolically unhealthy obesity (MUO), which presents with insulin resistance, dyslipidemia, and increased cardiovascular risk
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