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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Doctors recommend B12 shots if the patient has a deficiency of this nutrient
Example Protocol: A first step might be daily injections of 1000 mcg of Vitamin B12 for a week
18 The most bioavailable forms of B12 are methylcobalamin, hydroxocobalamin, and adenosylcobalamin
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