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In addition, GLP-1RAs are valuable in the treatment and prevention of diseases of the nervous and cardiovascular system, endocrine disorders, or metabolic diseases due to their neuroprotective, cardiovascular protective, and metabolic regulatory effects
Although these mice initially exhibit normal cardiac function, they progressively develop left ventricular dilation, reduced fractional shortening, disorganized sarcomeres, and damaged mitochondria with aging, highlighting the essential role of sustained autophagy in maintaining structural integrity and contractile function over time
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