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doi: 10.1681/ASN.2013080902 54 ZhangJ.McCulloughP
Pathologically, ALS is characterized by motor neuron degeneration and a constellation of co-occurring molecular abnormalities, including excitotoxicity, mitochondrial dysfunction, oxidative stress, necrosis, altered proteostasis, impaired cytoskeletal trafficking, DNA damage, and dysfunctional RNA metabolism
Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed sulfation factor, which later became known as somatomedin
Implications for neurodegenerative diseases The potential for GLP-1R agonism to protect the brain and improve cognitive function has spurred interest in its use as a therapeutic strategy for neurodegenerative diseases like Alzheimer's
Clinical Recognition and Therapeutic Development (1980Present) The shift from biochemical curiosity to clinical intervention accelerated in the 1980s when Dean Jones at Emory University demonstrated that glutathione status could be manipulated therapeutically using N-acetylcysteine (NAC), a precursor that bypasses the rate-limiting step in glutathione synthesis
