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Troglitazone Troglitazone was the first TZD approved for use in the United States and was licensed for use in T2DM in 1997, but withdrawn 3 years later because of the frequency of liver injury, including acute liver failure, associated with its use
This often leads to a significant decrease in food consumption
In Germany, about one in ten individuals is affected by diabetes and it is currently estimated that the number of diabetes patients worldwide will rise to about half a billion over the next 20 years
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doi: 10.4103/2152-7806.174896
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