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One of the most well-documented oxidative DNA adducts is 8-OHdG, which results from the oxidation of guanine ( Figure 2 The process of DNA fragmentation begins when ROS attack the deoxyribose backbone of DNA, leading to the cleavage of phosphodiester bonds and the formation of strand breaks ( One of the major challenges in addressing oxidative DNA damage in sperm is the limited DNA repair capacity of spermatozoa

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