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Published research compares NAC, oral glutathione, and sublingual glutathione head-to-head (Schmitt et al., 2015)

For people with MTHFR variants, supplementing with the active form is often what makes the difference between methylation working and methylation falling short

However, it is important to note that their statistical analysis indicated that the statistical significance of the score improvements was stronger in the placebo group than it was in either of the treatment groups

What they did: Obese mice received AOD-9604 orally (via gavage) for 14 days at various doses (50, 250, 500 g/kg)

The plasma level of GHK is about 200 ng/ml at age 20 but declines to 80 ng/ml by age 60