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Eli Lilly developed it, and a Phase 2 trial published in the New England Journal of Medicine in 2023 enrolled 338 adults with obesity and reported a mean body-weight reduction of 24.2% at 48 weeks on the 12mg once-weekly dose

Long-term use can lead to sustained weight loss and improvements in overall metabolic health

The savings are not worth the risk

If a dose is missed, your healthcare provider will advise whether to take it when remembered or wait until the next scheduled dose

These observations were also made with mechanistically different secondary stressors such as the mitochondrial complex I inhibitor, rotenone, or proteasomal inhibitors such as MG-132 or bortezomib (Suppl