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Furthermore, certain DAMPs, including HMGB1, S100 proteins, and IL-1, not only accelerate tumor progression but also contribute to resistance against anticancer therapies [239, 300, 301]
These interactions are further complicated by metabolic conditions such as obesity and diabetes, where hormonal resistance (e.g., leptin, insulin) and neurotransmitter dysregulation contribute to altered taste preferences and compulsive eating behaviors
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This protein binds specifically to reduced glutathione (GSH) in near-neutral, nondenaturing conditions (e.g., Tris buffer)
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