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However, these patients had multiple risk factors for b12 deficiency beyond semaglutide use, including previous gastric surgery that permanently alters stomach anatomy and reduces intrinsic factor production

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But it is an important consideration, given that the research published so far shows that when patients discontinue using these medications, their appetite returns, and the majority regain some or all of the weight they initially lost

Recent studies have indicated that GLP-1RAs may possess neuroprotective properties (12) and directly reduce ICP

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