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Is it an underlying medical condition, a nutrient deficiency, or simply a need for optimized nutritional support
Mechanistically, we found that insufficiency of vitamin B 12 during OSKM reprogramming resulted in changes in the bulk levels of many histone methylation marks, including a failure to properly trimethylate H3K36 at transcribed gene bodies, leading to increased levels of CT
That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route
Several drugs, including colchicine, have been reported to reduce the absorption of methylcobalamin, vitamin B12
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