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Notably, in Arabidopsis thaliana the mutation of arGST tt19 completely eliminates production of epicatechin 34 an unexpected outcome in the frame of the ligandin model as the cytosolic availability of cyanidin ( 8-AH + ), the precursor molecule of epicatechin ( 19 ), should be unaffected by mutating a transport protein

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5 CR reduces fasting insulin levels and improves insulin sensitivity in overweight individuals, whereby these effects may be more pronounced with regular IF compared with chronic CR

J Biol Chem 247:31703175