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GIP also plays a role in insulin release and appears to enhance the fat-loss effects of GLP-1 agonism while potentially mitigating some side effects
included 41 patients with newly diagnosed DM2 and high risk of CV events with CAD, showed the effect of the combination of liraglutide and metformin on the lipid subfractions and markers of low-grade inflammation
Both are E3 ubiquitin ligases that drive muscle protein breakdown (Sacheck et al., 2004)
doi:10.1016/j.ympev.2004.10.024
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