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You should work with your counsel when making these decisions, as this is a developing area that can potentially trigger various compliance issues, including issues beyond the scope of these FAQs.
For those with certain conditions like heart failure, renal impairment, or autonomic neuropathy, extra caution is warranted when combining these medications
That is why its important not to stop or change the dosing on your medications without first speaking to your healthcare provider
for example, in MASH, the abnormal accumulation of lipotoxic species, such as ceramides and diacylglycerols (DAGs), triggers inflammatory signaling that antagonizes receptor-mediated protection (Steinberg et al., 2025)
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