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TEN significantly reduced glial fibrillary acidic protein immunoreactivity and astrocyte activation, implying that its analgesic effects are associated with suppression of spinal astrocytes and neuroinflammation [36, 37]
It is typically administered via subcutaneous injection in a titrated daily dose, carefully increasing over several weeks to achieve desired tanning effects while minimizing side effects
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Nature 555 , 121125 (2018)
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