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FDA-approved Crohn's treatments include biologic therapies (infliximab, adalimumab, vedolizumab, ustekinumab, risankizumab), JAK inhibitors (upadacitinib), corticosteroids for induction (budesonide, prednisone), and immunomodulators (azathioprine, methotrexate)

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That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route

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