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Whats more, many biomarkers associated with resistance have not yet been sufficiently validated for routine clinical use, and assay standardization, sampling heterogeneity, and data interpretation remain unresolved

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The study included patients with renal insufficiency classified on the basis of creatinine clearance as mild (50 to less than 80 mL/min), moderate (30 to less than 50 mL/min), and severe (less than 30 mL/min), as well as patients with ESRD on hemodialysis

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