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Fumarate has recently been established as a terminal electron acceptor in the mammalian electron transport chain, together with oxygen, under normal conditions in certain tissues such as the liver, kidney, and brain, and it helps to maintain mitochondrial function under oxygen limitation [57]
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Cellular analysis using flow cytometry suggested that GHK may reduce overall reactive oxygen species levels under oxidative challenge conditions
No human studies have assessed chronic administration effects on brain structure, function, or neurotransmitter systems
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