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Cloning and site-directed mutagenesis All plasmids and primers for cloning and site-directed mutagenesis are listed as separate Supplementary Data

Glutathione binds undesirable toxins, pollutants, chemicals, heavy metals, and drug metabolites and excretes them through the urine or the gut

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However, the impact of GSH itself, its role in B cell metabolism and B cell responses has so far been elusive

191 Conclusions In summary, the essential role of NADPH homeostasis has been increasingly recognized in cancer development and progression through cellular antioxidative effects and anabolic reactions