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These mechanisms are specific to the hair follicle microenvironment
By enhancing microbial production of short-chain fatty acids (SCFAs), VD fosters extrathymic Treg differentiation and attenuates proinflammatory cytokine release in macrophages [84]
You are not doubling down on one pathway
In db/db mice and HG-exposed HK-2 cells, overexpression of mitofusin 2 restores mitochondrial function, suppresses mitochondrial oxidative phosphorylation, reduces tubular apoptosis and eventually alleviates diabetic kidney injury, and the reverse tendency is observed in mitofusin 2 short hairpin RNA treated db/db mice (82)
By reducing free radical damage, it helps maintain a youthful and productive follicle environment
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