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A randomized trial found that low-dose semaglutide significantly decreased: The amount of alcohol consumed during laboratory self-administration tasks 22 Weekly alcohol cravings compared to placebo 22 Drinks per drinking day 22 The magnitude of these effects appears substantial, with medium to large effect sizes for grams of alcohol consumed (, 0.48) and peak breath alcohol concentration (, 0.46) 22

Pharmacology Biochemistry and Behavior

We, for the first time, show that an L-carnitine oral challenge increases brain GBB levels in E2 and E4 mice (but not in E3 males) and brain crotonobetaine only in E4 mice

Yamaguchi T, Katoh I, Kurata S